XIST

Across TCGA pan-cancer cohorts, XIST RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated XIST data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher XIST RNA is associated with worse overall survival. In most high-consensus cancer types, elevated XIST expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

KIRP, KIRC, and LUSC are the cancer types where XIST RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.580	0.766	<.001	97	view →
KIRC	OS	Median	All	0.546	0.741	<.001	43	view →
LUSC	OS	Quartile	II,III,IV	0.241	0.623	.015	26	view →
MESO	DFS	Quartile	IV	0.240	0.713	.003	24	view →
LUAD	DFS	Median	IV	0.491	0.855	.004	22	view →
LGG	OS	Median	All	0.731	0.921	<.001	18	view →
BRCA	DFS	Quartile	III,IV	0.937	0.778	.007	13	view →
SKCM	DFS	Quartile	All	0.330	0.166	.005	11	view →
TGCT	DFS	Quartile	All	0.970	0.669	.003	10	view →
GBM	OS	Median	All	0.200	0.323	.004	9	view →
HNSC	OS	Quartile	III,IV	0.512	0.867	.002	9	view →
COAD	DFS	Tertile	III,IV	0.513	0.805	.022	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

XIST–KIRP (OS)

Open the KIRP breakdown →