XIST

Across TCGA pan-cancer cohorts, XIST RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of XIST’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where XIST RNA is repressed in tumor relative to normal tissue. In most cancer types XIST is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and READ are the cancer types where XIST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XIST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.880	<.001	4	view →
BRCA	Female	All	−0.622	.003	2	view →
READ	Female	All	+1.398	.008	1	view →
KIRC	Female	All	+0.712	.039	1	view →
LUAD	Male	All	+0.033	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

XIST–KICH

Open the KICH breakdown →