XCL1

Across TCGA patient cohorts, XCL1 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XCL1-associated genes across cancer lineages are ATP6V1E1P2, MIR3179-2, and SPEM1. Each is linked with XCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XCL1-to-partner and partner-to-XCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1E1P2 grouped by XCL1-low versus XCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XCL1→partner) and Y-score (partner→XCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1E1P2 →	+0.275	+3.077	<.001	.005	3	2
LUSC	MIR3179-2 →	+0.388	+7.924	<.001	.008	3	2
UCEC	SPEM1 →	+0.190	+3.155	.007	.004	3	1
UCEC	TRAJ57 →	+0.698	+3.318	<.001	.003	3	1
UCEC	RNA5SP424 →	+0.322	+3.505	<.001	.005	3	1
UCEC	RNU4-53P →	+0.559	+3.385	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

ATP6V1E1P2 by XCL1 expression — UCEC

Explore this box plot interactively →