XCL1

Across TCGA pan-cancer cohorts, XCL1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of XCL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where XCL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types XCL1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where XCL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XCL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.672	<.001	11	view →
KIRC	Male	IV	+1.338	<.001	11	view →
BLCA	All	All	+1.224	.002	6	view →
THCA	All	All	−0.435	.003	6	view →
COAD	All	All	−0.411	.012	5	view →
KICH	All	All	−0.305	.003	5	view →
LUSC	All	All	+0.576	.003	3	view →
LUAD	All	II,III,IV	−0.565	.010	2	view →
BRCA	Female	II,III,IV	−0.229	.036	2	view →
LIHC	Female	II,III,IV	+0.641	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

XCL1–HNSC

Open the HNSC breakdown →