XAGE5

Across TCGA patient cohorts, XAGE5 mutation is significantly associated with the RNA expression of many other genes, with 337 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible XAGE5-associated genes across cancer lineages are LINC02460, AGGF1P7, and OR7A3P. Each is linked with XAGE5 in more than 1 cancer types. Because this analysis shows association rather than direction, both XAGE5-to-partner and partner-to-XAGE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02460 grouped by XAGE5-low versus XAGE5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XAGE5→partner) and Y-score (partner→XAGE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02460 →	+0.055	+4.704	<.001	.005	3	2
BLCA	AGGF1P7 →	+0.035	+5.722	<.001	.001	3	2
BLCA	OR7A3P →	+0.026	+4.704	<.001	.005	3	2
BLCA	NDE1P2 →	+0.027	+4.314	<.001	.009	3	2
LUSC	RNA5SP407 →	+0.414	+7.339	<.001	<.001	3	2
LUSC	ANHX →	+0.505	+4.416	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 337 associations by consensus.

LINC02460 by XAGE5 expression — BLCA

Explore this box plot interactively →