XAB2

Across TCGA cell cohorts, XAB2 mutation is significantly associated with the RNA expression of many other genes, with 263 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XAB2-associated genes across cancer lineages are GPR26, C10orf71, and ZNRF4. Each is linked with XAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XAB2-to-partner and partner-to-XAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by XAB2-low versus XAB2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XAB2→partner) and Y-score (partner→XAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR26 →	+0.036	+4.906	<.001	.006	3	1
OESOPHAGUS	C10orf71 →	+0.006	+4.906	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	ZNRF4 →	+0.028	+3.624	.004	.001	3	1
UPPER_AERODIGESTIVE_TRACT	PANX3 →	+0.027	+3.691	.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	PLSCR5 →	+0.039	+3.129	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	OR1P1 →	+0.084	+3.906	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 263 associations by consensus.

GPR26 by XAB2 expression — OESOPHAGUS

Explore this box plot interactively →