XAB2

Across TCGA pan-cancer cohorts, XAB2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of XAB2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where XAB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types XAB2 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where XAB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XAB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.060	<.001	10	view →
LIHC	Female	II,III,IV	+1.119	<.001	9	view →
HNSC	Male	IV	+0.744	<.001	8	view →
STAD	Male	II,III,IV	+0.652	.002	6	view →
KIRP	All	II,III,IV	+0.323	.016	4	view →
LUSC	All	II,III,IV	+0.309	.022	4	view →
CHOL	All	All	+1.668	<.001	3	view →
LUAD	All	All	−0.253	.003	3	view →
ESCA	All	All	+0.542	.008	2	view →
KICH	All	All	−0.495	.001	2	view →
READ	All	All	+0.394	.018	2	view →
UCEC	All	All	−0.390	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

XAB2–COAD

Open the COAD breakdown →