Across TCGA patient cohorts, WWOX protein abundance is significantly associated with the RNA expression of many other genes, with 6,156 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible WWOX-associated genes across cancer lineages are ITGB1, MYOSLID, and KIF20B. Each is linked with WWOX in more than 3 cancer types. Because this analysis shows association rather than direction, both WWOX-to-partner and partner-to-WWOX results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWOX→partner) and Y-score (partner→WWOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGB1 →	-0.665	-0.302	<.001	<.001	3	4
HNSC	MYOSLID →	-0.741	-0.303	.006	.002	3	4
LUAD	KIF20B →	-0.547	-0.316	<.001	<.001	3	3
LUAD	HAUS6 →	-0.479	-0.321	<.001	.001	3	3
UCEC	GTF2E1 →	-0.448	-0.283	<.001	<.001	3	3
UCEC	SUPV3L1 →	-0.266	-0.210	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,156 associations by consensus.

Exploration

WWOX survival (RNA) · tumor vs normal (RNA) · all WWOX data types