WWC2

Across TCGA cell cohorts, WWC2 mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWC2-associated genes across cancer lineages are CCDC196, LY6G6F, and AMY2A. Each is linked with WWC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WWC2-to-partner and partner-to-WWC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC196 grouped by WWC2-low versus WWC2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC2→partner) and Y-score (partner→WWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CCDC196 →	+0.017	+5.044	<.001	<.001	3	1
URINARY_TRACT	LY6G6F →	+0.030	+4.087	<.001	.009	3	1
BLOOD_Lymphoma	AMY2A →	+0.099	+3.954	<.001	.005	3	1
OVARY	OR2AK2 →	+0.060	+4.029	<.001	.009	3	1
LUNG_SCLC	OR2M7 →	+0.030	+4.643	<.001	.004	3	1
LUNG_SCLC	OR13D1 →	+0.029	+4.269	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

CCDC196 by WWC2 expression — URINARY_TRACT

Explore this box plot interactively →