WWC2

Across TCGA pan-cancer cohorts, WWC2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of WWC2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where WWC2 RNA is repressed in tumor relative to normal tissue. In most cancer types WWC2 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and THCA are the cancer types where WWC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WWC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−3.157	<.001	9	view →
LUAD	Female	III,IV	−2.696	<.001	9	view →
THCA	All	II,III,IV	−0.756	.002	8	view →
HNSC	All	All	+0.561	<.001	8	view →
KICH	Female	All	−1.429	<.001	7	view →
KIRP	Male	All	−1.262	<.001	7	view →
KIRC	Male	II,III,IV	−0.657	<.001	6	view →
BRCA	Female	All	−0.300	.005	6	view →
UCEC	All	All	−0.610	.011	2	view →
READ	All	III,IV	+0.575	.018	2	view →
PRAD	All	All	−0.326	.015	2	view →
CHOL	Female	All	+0.819	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

WWC2–LUSC

Open the LUSC breakdown →