WNT7A

Across TCGA cell cohorts, WNT7A mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WNT7A-associated genes across cancer lineages are AVP, OR9G4, and POTEB2. Each is linked with WNT7A in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT7A-to-partner and partner-to-WNT7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by WNT7A-low versus WNT7A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT7A→partner) and Y-score (partner→WNT7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
LUNG_NSCLC_LUAD	OR9G4 →	+0.039	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	POTEB2 →	+0.026	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	POTEB →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MYH7 →	+0.016	+4.887	<.001	.009	3	1
BLOOD_Leukemia	C1orf94 →	+0.088	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

AVP by WNT7A expression — BLOOD_Lymphoma

Explore this box plot interactively →