WNT7A

Across TCGA pan-cancer cohorts, WNT7A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WNT7A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WNT7A RNA is repressed in tumor relative to normal tissue. In most cancer types WNT7A is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and HNSC are the cancer types where WNT7A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT7A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.075	<.001	12	view →
LUAD	Male	All	−2.310	<.001	11	view →
HNSC	Female	III,IV	+2.694	<.001	10	view →
KICH	All	II,III,IV	−1.206	<.001	8	view →
LUSC	Female	III,IV	−2.800	<.001	7	view →
THCA	All	All	+0.335	<.001	6	view →
PAAD	All	All	+2.009	.014	4	view →
COAD	All	All	+0.201	.009	4	view →
LIHC	Male	II,III,IV	−0.071	.002	4	view →
BLCA	Male	III,IV	+1.898	.020	2	view →
UCEC	All	IV	−1.204	.039	2	view →
PRAD	All	All	−0.329	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WNT7A–KIRC

Open the KIRC breakdown →