WNT5B

Across TCGA patient cohorts, WNT5B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT5B-associated genes across cancer lineages are MSH2, eEF2, and GATA6. Each is linked with WNT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT5B-to-partner and partner-to-WNT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by WNT5B-low versus WNT5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT5B→partner) and Y-score (partner→WNT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.427	-3.312	<.001	.010	3	2
UCEC	eEF2 →	+0.471	+3.000	.006	.036	3	1
UCEC	GATA6 →	-0.196	-2.314	.011	.035	3	1
UCEC	IGFBP2 →	-0.641	-2.459	.041	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.164	-2.446	.044	.020	3	1
UCEC	mTOR_pS2448 →	-0.213	-3.150	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MSH2 by WNT5B expression — UCEC

Explore this box plot interactively →