WNT5B

Across TCGA cell cohorts, WNT5B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible WNT5B-associated genes across cancer lineages are DBX2, ADAM30, and OR5B21. Each is linked with WNT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT5B-to-partner and partner-to-WNT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX2 grouped by WNT5B-low versus WNT5B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT5B→partner) and Y-score (partner→WNT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DBX2 →	+0.023	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	ADAM30 →	+0.006	+4.212	.008	.007	3	1
LUNG_NSCLC_LUAD	OR5B21 →	+0.051	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	LIPN →	+0.047	+4.947	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DBX2 by WNT5B expression — LARGE_INTESTINE

Explore this box plot interactively →