WNT5B

Across TCGA cell cohorts, WNT5B mutation is significantly associated with the mutation status of many other genes, with 967 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNT5B-associated genes across cancer lineages are DLG4, C7orf26, and JMY. Each is linked with WNT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT5B-to-partner and partner-to-WNT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLG4 grouped by WNT5B-low versus WNT5B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT5B→partner) and Y-score (partner→WNT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DLG4 →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	C7orf26 →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	JMY →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	SYCP2L →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	XPOT →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	RSC1A1 →	+5.924	+5.924	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 967 associations by consensus.

DLG4 by WNT5B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →