WNT2

Across TCGA patient cohorts, WNT2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,004 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WNT2-associated genes across cancer lineages are SERPINF1, PDGFRA, and FNDC1. Each is linked with WNT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both WNT2-to-partner and partner-to-WNT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WNT2 versus SERPINF1 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT2→partner) and Y-score (partner→WNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINF1 →	+0.783	+0.517	.004	.002	3	4
UCEC	PDGFRA →	+1.002	+0.609	.002	.004	3	4
LSCC	FNDC1 →	+1.122	+0.910	<.001	<.001	3	4
UCEC	HEPH →	+0.844	+0.594	.005	.009	3	4
PDAC	MEOX2 →	+0.760	+0.562	.002	<.001	3	4
LSCC	PDGFRB →	+0.704	+1.017	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,004 associations by consensus.

WNT2 vs SERPINF1 — BRCA

Explore this scatter interactively →