WNT2

Across TCGA pan-cancer cohorts, WNT2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated WNT2 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WNT2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated WNT2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, UVM, and COAD are the cancer types where WNT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	0.832	0.519	<.001	84	view →
UVM	OS	Median	III,IV	0.224	0.836	<.001	58	view →
COAD	OS	Quartile	III,IV	0.859	0.414	<.001	57	view →
LUAD	OS	Median	III,IV	0.651	0.340	.001	39	view →
DLBC	DFS	Tertile	IV	0.923	0.184	.006	28	view →
THYM	DFS	Median	II,III,IV	0.860	0.587	.003	18	view →
UCS	OS	Median	II,III,IV	0.632	0.349	.029	8	view →
KIRP	DFS	Tertile	III,IV	0.472	1.000	.030	8	view →
HNSC	DFS	Tertile	IV	0.751	0.582	.016	7	view →
GBM	OS	Tertile	All	0.267	0.501	.023	6	view →
STAD	OS	Median	IV	0.215	0.553	.037	5	view →
SKCM	DFS	Median	II,III,IV	0.379	0.246	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

WNT2–UCEC (OS)

Open the UCEC breakdown →