WNT2

Across TCGA pan-cancer cohorts, WNT2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WNT2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where WNT2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WNT2 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where WNT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+3.288	<.001	12	view →
HNSC	Female	III,IV	+2.363	<.001	12	view →
BLCA	All	All	+1.836	<.001	11	view →
KIRC	Male	All	−0.578	<.001	11	view →
STAD	Male	II,III,IV	+2.012	<.001	9	view →
LUSC	Female	All	−1.618	<.001	7	view →
LIHC	Male	III,IV	−0.788	<.001	7	view →
BRCA	All	III,IV	+1.359	<.001	6	view →
LUAD	Female	All	−0.871	<.001	6	view →
READ	All	All	+2.882	<.001	5	view →
ESCA	All	All	+1.651	.022	2	view →
PRAD	All	All	−0.654	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WNT2–COAD

Open the COAD breakdown →