WNT2

Across TCGA patient cohorts, WNT2 mutation is significantly associated with the RNA expression of many other genes, with 2,169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT2-associated genes across cancer lineages are CDY3P, RNA5SP84, and RNU4-73P. Each is linked with WNT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both WNT2-to-partner and partner-to-WNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDY3P grouped by WNT2-low versus WNT2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT2→partner) and Y-score (partner→WNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	CDY3P →	+0.030	+5.691	<.001	<.001	3	4
HNSC	RNA5SP84 →	+0.362	+5.023	<.001	.003	3	3
BLCA	RNU4-73P →	+0.215	+4.685	<.001	.007	3	2
HNSC	RNU6-562P →	+0.278	+4.526	<.001	.007	3	2
READ	TAS2R8 →	+0.062	+5.594	<.001	<.001	3	2
READ	RN7SL22P →	+0.205	+4.624	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,169 associations by consensus.

CDY3P by WNT2 expression — READ

Explore this box plot interactively →