WNT2

Across TCGA patient cohorts, WNT2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT2-associated genes across cancer lineages are 4E-BP1_pT37_T46, Notch1, and p38-MAPK_pT180_Y182. Each is linked with WNT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT2-to-partner and partner-to-WNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by WNT2-low versus WNT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT2→partner) and Y-score (partner→WNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.506	-3.156	.002	.018	3	2
UCEC	Notch1 →	+0.203	+2.331	.001	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.460	-3.169	.023	.019	3	1
UCEC	14-3-3_epsilon →	+0.090	+2.700	.044	.006	3	1
UCEC	PCNA →	+0.260	+3.169	.007	.018	3	1
UCEC	PDCD4 →	-0.703	-2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

4E-BP1_pT37_T46 by WNT2 expression — UCEC

Explore this box plot interactively →