WNT2

Across TCGA cell cohorts, WNT2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNT2-associated genes across cancer lineages are OR56A1, S100A7A, and TAS2R60. Each is linked with WNT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT2-to-partner and partner-to-WNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A1 grouped by WNT2-low versus WNT2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT2→partner) and Y-score (partner→WNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR56A1 →	+0.028	+3.523	.001	.009	3	1
BLOOD_Lymphoma	S100A7A →	+0.021	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	TAS2R60 →	+0.048	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.026	+4.662	<.001	.003	3	1
LARGE_INTESTINE	BRDT →	+0.092	+2.906	<.001	.007	3	1
LARGE_INTESTINE	RASGEF1C →	+0.223	+3.555	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR56A1 by WNT2 expression — BLOOD_Lymphoma

Explore this box plot interactively →