WNT10B

Across TCGA patient cohorts, WNT10B mutation is significantly associated with the RNA expression of many other genes, with 546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT10B-associated genes across cancer lineages are RNU1-17P, MAGEA2B, and RNU6-454P. Each is linked with WNT10B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT10B-to-partner and partner-to-WNT10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by WNT10B-low versus WNT10B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT10B→partner) and Y-score (partner→WNT10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-17P →	+0.398	+5.103	<.001	.008	3	2
LUAD	MAGEA2B →	+0.303	+4.533	<.001	<.001	3	2
LUAD	RNU6-454P →	+0.167	+5.924	<.001	<.001	3	2
LUAD	RPL22P10 →	+0.231	+3.915	<.001	.004	3	2
LUAD	KRT18P32 →	+0.100	+3.745	<.001	.006	3	2
BLCA	CSAG4 →	+1.406	+3.638	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 546 associations by consensus.

RNU1-17P by WNT10B expression — CESC

Explore this box plot interactively →