WNT10B

Across TCGA pan-cancer cohorts, WNT10B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated WNT10B data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher WNT10B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WNT10B expression acts as an unfavorable survival marker, although some lineages such as PAAD and ESCA show a favorable association.

KIRC, UVM, and COAD are the cancer types where WNT10B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.536	0.714	<.001	160	view →
UVM	DFS	Median	All	0.332	0.830	<.001	157	view →
COAD	DFS	Median	II,III,IV	0.293	0.597	<.001	122	view →
ACC	DFS	Median	All	0.160	0.666	<.001	104	view →
MESO	OS	Quartile	III,IV	0.336	0.690	.001	76	view →
PAAD	DFS	Quartile	II,III,IV	0.631	0.351	.001	66	view →
PCPG	DFS	Median	All	0.544	0.876	.001	34	view →
ESCA	OS	Tertile	All	1.000	0.456	.008	25	view →
UCS	DFS	Median	II,III,IV	0.458	0.148	.020	18	view →
PRAD	DFS	Tertile	All	0.845	0.951	<.001	18	view →
LIHC	OS	Quartile	II,III,IV	0.879	0.704	.028	11	view →
STAD	DFS	Median	All	0.481	0.619	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

WNT10B–KIRC (OS)

Open the KIRC breakdown →