WNT10B

Across TCGA pan-cancer cohorts, WNT10B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WNT10B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where WNT10B RNA is repressed in tumor relative to normal tissue. In most cancer types WNT10B is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and LUSC are the cancer types where WNT10B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT10B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−1.440	<.001	10	view →
THCA	Male	All	−0.505	<.001	9	view →
LUSC	All	II,III,IV	+1.406	<.001	6	view →
BRCA	All	II,III,IV	−0.749	<.001	6	view →
KIRC	Male	II,III,IV	+0.190	<.001	6	view →
LUAD	Male	II,III,IV	+0.636	.009	3	view →
CHOL	All	All	+0.617	<.001	3	view →
HNSC	All	All	+0.463	.014	2	view →
ESCA	All	II,III,IV	−0.444	.046	2	view →
PRAD	All	All	+0.197	.008	2	view →
READ	All	All	−0.427	.034	1	view →
STAD	Male	All	−0.398	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WNT10B–BLCA

Open the BLCA breakdown →