WNT10B

Across TCGA cell cohorts, WNT10B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WNT10B-associated genes across cancer lineages are KCNA4, AADACL2, and MMP26. Each is linked with WNT10B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT10B-to-partner and partner-to-WNT10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA4 grouped by WNT10B-low versus WNT10B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT10B→partner) and Y-score (partner→WNT10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNA4 →	+0.028	+4.922	<.001	.009	3	1
BLOOD_Leukemia	AADACL2 →	+0.022	+4.922	<.001	.009	3	1
SKIN	MMP26 →	+0.026	+6.022	<.001	.001	3	1
LARGE_INTESTINE	TNP1 →	+0.128	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KCNA4 by WNT10B expression — BLOOD_Leukemia

Explore this box plot interactively →