WNT1

Across TCGA cell cohorts, WNT1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WNT1-associated genes across cancer lineages are SPRR4, KRTAP4-6, and SPRR5. Each is linked with WNT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT1-to-partner and partner-to-WNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR4 grouped by WNT1-low versus WNT1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT1→partner) and Y-score (partner→WNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPRR4 →	+0.057	+4.643	<.001	.004	3	1
LUNG_SCLC	KRTAP4-6 →	+0.052	+4.643	<.001	.004	3	1
LUNG_SCLC	SPRR5 →	+0.352	+4.643	<.001	.004	3	1
BLOOD_Leukemia	KHDC3L →	+0.219	+3.774	<.001	.008	3	1
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	MYMK →	+0.090	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SPRR4 by WNT1 expression — LUNG_SCLC

Explore this box plot interactively →