WNK4

Across TCGA cell cohorts, WNK4 mutation is significantly associated with the RNA expression of many other genes, with 567 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNK4-associated genes across cancer lineages are RNASE9, CFAP43, and KCNRG. Each is linked with WNK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNK4-to-partner and partner-to-WNK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE9 grouped by WNK4-low versus WNK4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK4→partner) and Y-score (partner→WNK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNASE9 →	+0.029	+5.029	<.001	.006	3	2
LARGE_INTESTINE	CFAP43 →	+0.354	+3.087	.005	.006	3	2
LARGE_INTESTINE	KCNRG →	+0.606	+2.743	<.001	.001	3	2
BLOOD_Leukemia	RABL2B →	+0.762	+3.199	.001	.007	3	2
LARGE_INTESTINE	WNT2B →	+0.464	+2.043	<.001	.008	3	2
LARGE_INTESTINE	AHI1 →	+1.027	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 567 associations by consensus.

RNASE9 by WNK4 expression — LUNG_SCLC

Explore this box plot interactively →