WNK4

Across TCGA pan-cancer cohorts, WNK4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated WNK4 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher WNK4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated WNK4 expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

ACC, UVM, and BRCA are the cancer types where WNK4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.408	0.821	<.001	137	view →
UVM	OS	Median	All	0.781	0.389	<.001	123	view →
BRCA	OS	Median	All	0.977	0.948	<.001	114	view →
PAAD	DFS	Quartile	All	0.484	0.177	<.001	58	view →
LUAD	DFS	Tertile	II,III,IV	0.647	0.859	.004	42	view →
KICH	DFS	Tertile	II,III,IV	1.000	0.626	.005	23	view →
LIHC	DFS	Tertile	III,IV	0.051	0.373	.001	23	view →
KIRP	DFS	Median	All	0.793	0.908	.005	23	view →
UCEC	DFS	Quartile	All	0.943	0.853	.010	18	view →
LGG	DFS	Median	All	0.796	0.865	.013	17	view →
SKCM	OS	Median	All	0.413	0.275	.007	14	view →
READ	OS	Quartile	III,IV	0.995	0.688	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

WNK4–ACC (OS)

Open the ACC breakdown →