WIZ

Across TCGA patient cohorts, WIZ protein abundance is significantly associated with the RNA expression of many other genes, with 20,267 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WIZ-associated genes across cancer lineages are MYBL2, E2F3, and HROB. Each is linked with WIZ in more than 6 cancer types. Because this analysis shows association rather than direction, both WIZ-to-partner and partner-to-WIZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WIZ versus MYBL2 in LUAD, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIZ→partner) and Y-score (partner→WIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYBL2 →	+1.434	+0.138	<.001	<.001	3	7
BRCA	E2F3 →	+0.800	+0.335	<.001	<.001	3	7
UCEC	HROB →	+0.934	+0.277	<.001	<.001	3	7
HNSC	TOP2A →	+1.188	+0.287	<.001	<.001	3	7
HNSC	PLK4 →	+0.905	+0.335	<.001	<.001	3	7
LSCC	GINS4 →	+0.759	+0.196	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,267 associations by consensus.

WIZ vs MYBL2 — LUAD

Explore this scatter interactively →