WIZ

Across TCGA pan-cancer cohorts, WIZ RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of WIZ’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where WIZ RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WIZ is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where WIZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WIZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.088	<.001	12	view →
COAD	Male	II,III,IV	+0.597	<.001	11	view →
LIHC	Female	II,III,IV	+1.605	<.001	9	view →
LUSC	Female	All	+0.895	<.001	7	view →
CHOL	Female	All	+2.106	<.001	5	view →
KIRC	Female	All	+0.467	<.001	5	view →
THCA	All	II,III,IV	−0.307	.002	5	view →
STAD	All	II,III,IV	+0.665	.010	4	view →
BRCA	All	II,III,IV	+0.324	<.001	4	view →
KIRP	All	II,III,IV	+0.458	.019	2	view →
ESCA	All	All	+0.727	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

WIZ–HNSC

Open the HNSC breakdown →