WIPI1

Across TCGA patient cohorts, WIPI1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIPI1-associated genes across cancer lineages are FoxM1, GSK3-a-b, and Ku80. Each is linked with WIPI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPI1-to-partner and partner-to-WIPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by WIPI1-low versus WIPI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPI1→partner) and Y-score (partner→WIPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.230	+2.700	.048	.006	3	1
UCEC	GSK3-a-b →	-0.138	-2.321	.023	.034	3	1
UCEC	Ku80 →	+0.260	+2.013	.014	.018	3	1
UCEC	MEK1 →	+0.373	+2.000	.023	.032	3	1
UCEC	MSH2 →	-0.228	-3.312	.028	.010	3	1
UCEC	Notch1 →	+0.224	+2.183	<.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FoxM1 by WIPI1 expression — UCEC

Explore this box plot interactively →