WIPI1

Across TCGA cell cohorts, WIPI1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WIPI1-associated genes across cancer lineages are OR52K2, OR52K1, and OR10T2. Each is linked with WIPI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPI1-to-partner and partner-to-WIPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52K2 grouped by WIPI1-low versus WIPI1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPI1→partner) and Y-score (partner→WIPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR52K2 →	+0.173	+6.357	<.001	<.001	3	1
CNS	OR52K1 →	+0.056	+5.754	<.001	.002	3	1
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	DPRX →	+0.109	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
LUNG_NSCLC_LUAD	PRM2 →	+0.046	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR52K2 by WIPI1 expression — CNS

Explore this box plot interactively →