WFDC8

Across TCGA patient cohorts, WFDC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,924 significant associations in total. STAD shows the largest number of these associations.

The most reproducible WFDC8-associated GO terms across cancer lineages are RNA-templated DNA biosynthetic process, Telomere maintenance, and Telomere maintenance via telomere lengthening. Each is linked with WFDC8 in more than 20 cancer types. Because this analysis shows association rather than direction, both WFDC8-to-partner and partner-to-WFDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA-templated DNA biosynthetic process grouped by WFDC8-low versus WFDC8-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC8→partner) and Y-score (partner→WFDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	RNA-templated DNA biosynthetic process →	+0.074	+0.286	<.001	.005	3	21
STAD	Telomere maintenance →	+0.059	+0.110	<.001	<.001	3	19
ESCA	Telomere maintenance via telomere lengthening →	+0.077	+0.178	<.001	<.001	3	19
STAD	Transcription initiation at RNA polymerase II promoter →	+0.056	+0.113	<.001	<.001	3	18
SCLC	Nuclear-transcribed mRNA catabolic process →	+0.083	+0.338	<.001	<.001	3	18
STAD	Positive regulation of DNA metabolic process →	+0.057	+0.111	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,924 associations by consensus.

RNA-templated DNA biosynthetic process by WFDC8 expression — SCLC

Explore this box plot interactively →