WFDC8

Across TCGA patient cohorts, WFDC8 mutation is significantly associated with the RNA expression of many other genes, with 400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC8-associated genes across cancer lineages are KRT18P44, VENTXP8, and CCL7. Each is linked with WFDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC8-to-partner and partner-to-WFDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT18P44 grouped by WFDC8-low versus WFDC8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC8→partner) and Y-score (partner→WFDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KRT18P44 →	+0.009	+2.965	<.001	.008	3	2
SKCM	VENTXP8 →	+0.348	+2.463	<.001	.001	3	2
SKCM	CCL7 →	+0.997	+3.468	<.001	.002	3	2
UCEC	TRAJ42 →	+0.705	+2.232	<.001	.007	3	2
GBM	YWHAEP3 →	+0.408	+5.584	<.001	.003	3	1
GBM	PDLIM1P2 →	+0.102	+5.352	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 400 associations by consensus.

KRT18P44 by WFDC8 expression — SKCM

Explore this box plot interactively →