WFDC8

Across TCGA patient cohorts, WFDC8 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC8-associated genes across cancer lineages are S6_pS235_S236, PI3K-p85, and Tuberin. Each is linked with WFDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC8-to-partner and partner-to-WFDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS235_S236 grouped by WFDC8-low versus WFDC8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC8→partner) and Y-score (partner→WFDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	S6_pS235_S236 →	+0.504	+3.012	.017	.018	3	1
UCEC	PI3K-p85 →	+0.351	+3.179	<.001	.010	3	1
UCEC	Tuberin →	+0.393	+2.817	.003	.036	2	1
UCEC	AMPK_pT172 →	+0.446	+2.335	.030	.020	1	1
UCEC	Annexin-1 →	+0.613	+3.459	.020	.005	1	1
UCEC	STAT5a →	+0.589	+2.321	.003	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

S6_pS235_S236 by WFDC8 expression — SKCM

Explore this box plot interactively →