WFDC8

Across TCGA cell cohorts, WFDC8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible WFDC8-associated genes across cancer lineages are MOS, OR4F6, and KRTAP19-2. Each is linked with WFDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC8-to-partner and partner-to-WFDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MOS grouped by WFDC8-low versus WFDC8-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC8→partner) and Y-score (partner→WFDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MOS →	+0.047	+4.981	<.001	.008	3	1
CNS	OR4F6 →	+0.015	+5.321	<.001	.005	3	1
CNS	KRTAP19-2 →	+0.100	+5.754	<.001	.002	3	1
CNS	PRAMEF19 →	+0.072	+5.321	<.001	.005	3	1
CNS	KRTAP19-3 →	+0.082	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MOS by WFDC8 expression — CNS

Explore this box plot interactively →