WFDC5

Across TCGA patient cohorts, WFDC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,980 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC5-associated GO terms across cancer lineages are Establishment of skin barrier, Hemidesmosome assembly, and Epidermal cell differentiation. Each is linked with WFDC5 in more than 13 cancer types. Because this analysis shows association rather than direction, both WFDC5-to-partner and partner-to-WFDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of skin barrier grouped by WFDC5-low versus WFDC5-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC5→partner) and Y-score (partner→WFDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Establishment of skin barrier →	+0.084	+1.765	<.001	<.001	3	14
ESCA	Hemidesmosome assembly →	+0.122	+1.931	<.001	<.001	3	13
ESCA	Epidermal cell differentiation →	+0.074	+2.404	<.001	<.001	3	13
ESCA	Keratinocyte differentiation →	+0.101	+2.959	<.001	<.001	3	12
TGCT	Regulation of protein localization to lysosome →	+0.045	+0.502	<.001	<.001	3	12
ESCA	Skin epidermis development →	+0.048	+1.790	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,980 associations by consensus.

Establishment of skin barrier by WFDC5 expression — ESCA

Explore this box plot interactively →