WFDC5

Across TCGA pan-cancer cohorts, WFDC5 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated WFDC5 data layer compared with 3 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher WFDC5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WFDC5 expression acts as an unfavorable survival marker, although some lineages such as KIRP and ESCA show a favorable association.

OV, KIRC, and KIRP are the cancer types where WFDC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.474	0.597	<.001	140	view →
KIRC	DFS	Median	All	0.521	0.729	<.001	136	view →
KIRP	OS	Median	All	0.946	0.816	<.001	73	view →
SKCM	OS	Tertile	All	0.665	0.827	<.001	41	view →
MESO	DFS	Tertile	III,IV	0.118	0.574	<.001	35	view →
ESCA	OS	Quartile	III,IV	0.678	0.378	.011	27	view →
CESC	DFS	Quartile	All	0.818	0.621	.003	22	view →
UVM	OS	Tertile	III,IV	0.253	0.706	.012	18	view →
CHOL	OS	Tertile	All	0.253	0.771	.001	18	view →
LUSC	DFS	Median	II,III,IV	0.464	0.305	.013	18	view →
PCPG	DFS	Tertile	All	0.487	0.869	<.001	18	view →
BLCA	OS	Median	II,III,IV	0.762	0.672	.027	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

WFDC5–OV (DFS)

Open the OV breakdown →