WFDC5

Across TCGA pan-cancer cohorts, WFDC5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of WFDC5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where WFDC5 RNA is repressed in tumor relative to normal tissue. In most cancer types WFDC5 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where WFDC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WFDC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.207	<.001	8	view →
LUAD	Male	II,III,IV	−0.720	<.001	7	view →
LUSC	Male	All	+2.738	<.001	6	view →
HNSC	All	All	+1.173	.004	6	view →
KIRC	All	II,III,IV	−0.512	.004	3	view →
KIRP	All	All	+1.016	.008	2	view →
PRAD	All	All	−0.650	.033	2	view →
BRCA	All	III,IV	−0.244	.021	2	view →
THCA	All	II,III,IV	−0.168	.009	2	view →
COAD	All	All	−0.055	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

WFDC5–KICH

Open the KICH breakdown →