WFDC5

Across TCGA patient cohorts, WFDC5 mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible WFDC5-associated genes across cancer lineages are IGKV3D-34, RNU6-739P, and RN7SL504P. Each is linked with WFDC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC5-to-partner and partner-to-WFDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV3D-34 grouped by WFDC5-low versus WFDC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC5→partner) and Y-score (partner→WFDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGKV3D-34 →	+0.121	+5.332	<.001	.002	3	2
SKCM	RNU6-739P →	+0.308	+6.219	<.001	<.001	3	2
LUSC	RN7SL504P →	+0.235	+6.438	<.001	.001	3	2
BRCA	MIR6749 →	+0.345	+5.950	<.001	.001	3	1
BRCA	NPIPA2 →	+0.024	+6.342	<.001	<.001	3	1
BRCA	TPRX2P →	+0.030	+4.540	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

IGKV3D-34 by WFDC5 expression — COAD

Explore this box plot interactively →