WFDC11

Across TCGA patient cohorts, WFDC11 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC11-associated genes across cancer lineages are RNA5SP411, RNA5SP422, and RNA5SP407. Each is linked with WFDC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC11-to-partner and partner-to-WFDC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by WFDC11-low versus WFDC11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC11→partner) and Y-score (partner→WFDC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.654	+3.393	<.001	.007	3	2
UCEC	RNA5SP422 →	+1.087	+3.671	.001	.003	3	2
LUSC	RNA5SP407 →	+0.397	+7.924	<.001	.008	3	2
UCEC	MIR8080 →	+0.268	+4.335	<.001	.007	3	1
UCEC	RNA5SP412 →	+0.708	+3.967	.009	.001	3	1
UCEC	RNA5SP394 →	+0.376	+4.453	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RNA5SP411 by WFDC11 expression — UCEC

Explore this box plot interactively →