WFDC11

Across TCGA pan-cancer cohorts, WFDC11 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated WFDC11 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher WFDC11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WFDC11 expression acts as an unfavorable survival marker, although some lineages such as SARC and LUAD show a favorable association.

KIRC, SCLC, and TGCT are the cancer types where WFDC11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.419	0.683	<.001	82	view →
SCLC	OS	Tertile	II,III,IV	0.164	0.819	<.001	54	view →
TGCT	OS	Tertile	III,IV	0.003	1.000	<.001	54	view →
LIHC	DFS	Tertile	All	0.062	0.531	<.001	45	view →
KIRP	DFS	Tertile	III,IV	0.040	0.691	<.001	45	view →
READ	DFS	Quartile	All	0.687	0.912	.002	41	view →
ACC	DFS	Tertile	II,III,IV	0.137	0.753	<.001	27	view →
COAD	DFS	Tertile	All	0.494	0.735	.001	27	view →
THCA	OS	Tertile	All	0.726	0.962	.011	21	view →
SARC	OS	Median	All	0.926	0.757	.001	12	view →
LUAD	OS	Median	II,III,IV	0.313	0.147	.019	9	view →
SKCM	OS	Tertile	All	0.504	0.285	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

WFDC11–KIRC (DFS)

Open the KIRC breakdown →