WFDC11

Across TCGA pan-cancer cohorts, WFDC11 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of WFDC11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where WFDC11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WFDC11 is over-expressed in tumor, although a few such as PRAD and LUSC show the opposite, repressed pattern.

COAD, THCA, and PRAD are the cancer types where WFDC11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WFDC11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.075	.010	8	view →
THCA	All	All	+0.045	.002	2	view →
PRAD	All	All	−0.045	.016	2	view →
LUSC	All	All	−0.042	.016	2	view →
READ	All	II,III,IV	+0.265	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

WFDC11–COAD

Open the COAD breakdown →