Across TCGA patient cohorts, WEE2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,044 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WEE2-associated proteins across cancer lineages are RPS23, SIN3A, and SPIN1. Each is linked with WEE2 in more than 3 cancer types. Because this analysis shows association rather than direction, both WEE2-to-partner and partner-to-WEE2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WEE2→partner) and Y-score (partner→WEE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS23 →	-0.262	-0.200	<.001	<.001	3	4
OV	SIN3A →	+0.200	+0.232	.005	.006	3	4
LSCC	SPIN1 →	+0.306	+0.204	.001	.002	3	4
GBM	AZU1 →	-0.888	-0.330	.001	.001	3	4
BRCA	AGO1 →	+0.265	+0.185	<.001	.001	3	4
LSCC	ERO1A →	-0.532	-0.261	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,044 associations by consensus.

Exploration

WEE2 survival (RNA) · tumor vs normal (RNA) · all WEE2 data types