Across TCGA pan-cancer cohorts, WEE2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of WEE2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WEE2 RNA is repressed in tumor relative to normal tissue. In most cancer types WEE2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, KIRP, and KICH are the cancer types where WEE2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WEE2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.