WDR90

Across TCGA patient cohorts, WDR90 mutation is significantly associated with the RNA expression of many other genes, with 5,273 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR90-associated genes across cancer lineages are GLRX5, HES6, and RCHY1. Each is linked with WDR90 in more than 3 cancer types. Because this analysis shows association rather than direction, both WDR90-to-partner and partner-to-WDR90 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5 grouped by WDR90-low versus WDR90-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR90→partner) and Y-score (partner→WDR90) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLRX5 →	+0.263	+1.447	.007	.005	3	4
UCEC	HES6 →	+0.659	+1.869	.004	.004	3	4
UCEC	RCHY1 →	+0.495	+2.280	<.001	<.001	3	4
UCEC	LRR1 →	+0.580	+4.269	<.001	<.001	3	4
UCEC	RAD51 →	+0.597	+2.403	<.001	<.001	3	4
UCEC	WDR76 →	+0.821	+2.869	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,273 associations by consensus.

GLRX5 by WDR90 expression — UCEC

Explore this box plot interactively →