WDR90

Across TCGA pan-cancer cohorts, WDR90 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated WDR90 data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WDR90 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR90 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, ACC, and LGG are the cancer types where WDR90 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.747	0.644	<.001	143	view →
ACC	DFS	Quartile	All	0.435	1.000	.001	60	view →
LGG	DFS	Median	All	0.255	0.499	<.001	54	view →
BRCA	OS	Median	IV	0.879	0.353	<.001	40	view →
SKCM	DFS	Tertile	III,IV	0.129	0.519	<.001	34	view →
MESO	OS	Tertile	III,IV	0.264	0.875	.006	27	view →
KIRC	DFS	Quartile	All	0.520	0.706	.007	24	view →
LIHC	DFS	Median	All	0.480	0.601	.002	21	view →
LUAD	DFS	Tertile	IV	0.263	0.896	.014	18	view →
PRAD	DFS	Tertile	All	0.735	0.932	<.001	18	view →
THCA	OS	Quartile	II,III,IV	0.892	0.984	.017	16	view →
CHOL	DFS	Median	II,III,IV	0.098	0.595	.028	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

WDR90–HNSC (DFS)

Open the HNSC breakdown →