WDR88

Across TCGA patient cohorts, WDR88 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR88-associated genes across cancer lineages are MEK1, eIF4E, and p90 RSK. Each is linked with WDR88 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR88-to-partner and partner-to-WDR88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by WDR88-low versus WDR88-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR88→partner) and Y-score (partner→WDR88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.482	+3.807	<.001	<.001	3	3
LUSC	eIF4E →	+0.200	+2.816	.017	.036	2	3
UCEC	p90 RSK →	+0.192	+2.125	.009	.010	3	2
UCEC	PI3K-p85 →	+0.171	+1.884	.033	.030	3	2
UCEC	STAT3_pY705 →	-0.382	-2.212	<.001	.010	3	2
UCEC	STAT5a →	+0.328	+2.000	.032	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MEK1 by WDR88 expression — UCEC

Explore this box plot interactively →