WDR76

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, WDR76 mutation is significantly associated with the RNA expression of many other genes, with 1,467 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR76-associated genes across cancer lineages are RNU6-921P, MIR7976, and RN7SL478P. Each is linked with WDR76 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR76-to-partner and partner-to-WDR76 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-921P grouped by WDR76-low versus WDR76-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR76→partner) and Y-score (partner→WDR76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
READRNU6-921P →+0.561+5.421<.001.00532
UCECMIR7976 →+0.340+2.453.002.00232
UCECRN7SL478P →+0.228+2.032<.001.00432
SKCMMRPS33P2 →+0.090+3.669<.001.00632
LUSCRNU6-1163P →+0.442+4.984.001.00932
LUSCRNU6-203P →+0.485+5.978<.001.00232
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,467 associations by consensus.

RNU6-921P by WDR76 expression — READ

Box plot of RNU6-921P in WDR76-low vs WDR76-high samples in READ.

Explore this box plot interactively →

Exploration