WDR76

Across TCGA pan-cancer cohorts, WDR76 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of WDR76’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where WDR76 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR76 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where WDR76 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR76 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.178	<.001	12	view →
KIRC	Male	IV	+0.789	<.001	10	view →
LIHC	Female	II,III,IV	+1.634	<.001	9	view →
KIRP	All	III,IV	+0.863	<.001	9	view →
LUSC	Female	All	+1.739	<.001	8	view →
LUAD	Male	III,IV	+1.615	<.001	8	view →
BLCA	All	All	+1.382	<.001	8	view →
STAD	Male	II,III,IV	+1.261	<.001	8	view →
COAD	Female	II,III,IV	+0.994	<.001	8	view →
UCEC	All	III,IV	+1.703	<.001	6	view →
BRCA	All	III,IV	+1.266	<.001	6	view →
CHOL	All	All	+2.337	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

WDR76–HNSC

Open the HNSC breakdown →